Which of the following treatments is considered safe for immediate use in severe depression?

Antidepressants are considered safe for immediate use in managing severe depression because they are specifically designed to alter brain chemistry and improve mood by increasing the levels of neurotransmitters like serotonin, norepinephrine, and dopamine. These medications have been extensively researched and are commonly prescribed as a first-line treatment for various forms of depression, including major depressive disorder.

While the onset of their therapeutic effects may take several weeks, they are often part of a comprehensive treatment plan that includes therapy and lifestyle modifications. The choice of antidepressant may depend on the individual's specific symptoms, history, and potential side effects, but they are fundamentally safe and effective for addressing the symptoms of severe depression.

Other options, such as decongestants and antihistamines, are not designed to treat depression and can even have side effects that might exacerbate mood disorders. Stimulants, although sometimes used in specific situations like ADHD or treatment-resistant depression, are generally not the first line for treating severe depression and may come with significant risks, particularly if not monitored closely.